The heme‐containing cytochromes P‐450 are a ubiquitous family of monooxygenase isozymes responsible for the oxidative metabolism of a wide variety of endogenous as well as exogenous compounds. Many of the compounds metabolized by this enzyme system are effectively detoxified and converted to derivatives more easily eliminated from the organism. However, some compounds can be activated to reactive species capable of eliciting a cascade of toxic lesions, including cancer. Since its discovery nearly 30 years ago, the cytochrome P‐450 enzyme system has (...) received a great deal of attention, particularly in the areas of their mechanisms of metabolism, range of substrate specificity, the purification and characterization of the multiple isozymes and, more recently, the regulation of expression of specific forms. This review will discuss current notions concerning the expression of at least one cytochrome P‐450 isozyme and future directions that should lead to a more complete understanding of cytochrome P‐450 gene expression in general, particularly as it impacts upon biochemical pharmacology. (shrink)

The terms “competency” and “decision making capacity” are often used interchangeably in the medical setting. Although competency is a legal determination made by judges, “competency” assessments are frequently requested of psychiatrists who are called to consult on hospitalised patients who refuse medical treatment. In these situations, the bioethicist is called to consult frequently as well, sometimes as a second opinion or “tie breaker”. The psychiatric determination of competence, while a clinical phenomenon, is based primarily in legalism and can be quite (...) different from the bioethics approach. This discrepancy highlights the difficulties that arise when a patient is found to be “competent” by psychiatry but lacking in DMC by bioethics. Using a case, this dilemma is explored and guidance for reconciling the opinions of two distinct clinical specialties is offered. (shrink)

Spanish influence in the New World was particularly acute in the areas of medicine and medical education. From the time of Columbus forward prominent medical experts journeyed to Latin America establishing medical schools and research centers. This essay chronicles the history of Latin America with a strong focus on the physicians and scientists who brought modern scientific medicine, as it wag then known in Western Europe, to the Americas.

In this paper I argue that warrant for Lewis’ principle of recombination presupposes warrant for a combinatorial analysis of intrinsicality, which in turn presupposes warrant for the principle of recombination. This, I claim, leads to a vicious circularity: warrant for neither doctrine can get off the ground.

The relation of the conformal group to various earlier proposed relativistic quantum mechanical dynamical groups (and other related groups) is studied in the framework of projective geometry, by explicitly constructing the contractions of the six-dimensional coordinate transformations. Five-dimensional realizations are then derived. An attempt is made to improve our physical insight through geometry.

The article is a critique of malcolm and the wittgensteinians and their criticisms of russell which the author finds to be "prosecuting russell on false charges." (staff).

Petr Leonidovich Kapitsa, world-renowned physicist, often turns to themes that at first glance seem far removed from the sphere of his basic scientific interests. He is the author of numerous articles and papers on problems of the development of science and the organization of scientific work . Many have read with interest his remarkable recollections of Rutherford, published in Novy mir.

From the editors of Voprosy filosofii: The editors publish herewith the address by the ranking Soviet physicist Academician Petr Leonidovich Kapitsa, Director of the Institute of Physical Problems of the USSR Academy of Sciences, at the symposium, organized by UNESCO and held in Ulm, West Germany, in 1978, on the hundredth anniversary of the birth of Albert Einstein. The speech was graciously made available to us by Kapitsa. In it the Academician gives his principal attention to the global problems that (...) have interested him of late, on which he has already expressed himself in the pages of our journal . In the form and manner in which its problems are set forth, this address is designed chiefly for the scientists of Western countries present at the Ulm symposium. (shrink)

In his paper “Has Austin Refuted the Sense-Datum Theory?” A. J. Ayer contends that the argument from illusion calls attention to perspectival distortion, perceptual misidentification and elusive perceptual belief only in order to establish the possibility of perceptual error. Pointing to our occasional perceptual failures reminds us that perceptual error is always logically possible—that any particular perceptual belief to the effect that one is perceiving a physical surface could be mistaken. This in turn is thought by Ayer to show that (...) the ordinary belief that we perceive physical surfaces requires qualification—along lines urged by sense-datum philosophers—to the effect that even in those situations properly described for non-philosophical purposes as perceptions of physical surfaces it cannot be physical surfaces that are literally present to one's senses. Ayer believes that this can be established, for any given case, by the possibility of perceptual error alone. (shrink)

We recall some of the early occurrences of the notions of interactivity and symmetry in the operational and denotational semantics of programming languages. We suggest some connections with ludics.